Browsing by Author "Varas Godoy, Manuel"

Now showing items 1-8 of 8

    • An integrated mechanism of cardiomyocyte nuclear Ca2+ signaling 
      Ibarra, Cristián; Vicencio Bustamante, José Miguel; Varas Godoy, Manuel; Jaimovich Pérez, Enrique; Rothermel, Beverly A.; Uhlén, Per; Hill, Joseph A.; Lavandero González, Sergio (Academic Press, 2014)
      © 2014 Elsevier Ltd. In cardiomyocytes, Ca2+ plays a central role in governing both contraction and signaling events that regulate gene expression. Current evidence indicates that discrimination between these two critical ...
    • Caveolin-1-containing extracellular vesicles transport adhesion proteins and promote malignancy in breast ... 
      Campos, America; Salomon, Carlos; Bustos, Rocio; Díaz, Jorge; Martínez, Samuel; Silva, Veronica; Reyes, Constanza; Díaz Valdivia, Natalia; Varas Godoy, Manuel; Lobos González, Lorena; Quest, Andrew F. G. (Future Medicine Ltd., 2018)
      © 2018 2018 Future Medicine Ltd. Breast cancer is one of the most frequently diagnosed cancers and the leading cause of cancer-related deaths in women worldwide, whereby mortality is largely attributable to the development ...
    • CK2 inhibition with silmitasertib promotes methuosis-like cell death associated to catastrophic massive ... 
      Silva-Pavez, Eduardo; Villar, Paulina; Trigo, César; Caamaño, Esteban; Niechi, Ignacio; Pérez, Pablo; Muñoz, Juan P.; Aguayo, Francisco; Burzio, Verónica A.; Varas Godoy, Manuel; Castro, Ariel F.; Colombo, María I.; Tapia, Julio C. (Nature Publishing Group, 2019)
      Protein kinase CK2 is a highly conserved and constitutively active Ser/Thr-kinase that phosphorylates a large number of substrates, resulting in increased cell proliferation and survival. A known target of CK2 is Akt, a ...
    • Colon cancer cell invasion is promoted by protein kinase CK2 through increase of endothelin-converting ... 
      Niechi, Ignacio; Silva, Eduardo; Cabello, Pablo; Huerta, Hernán; Carrasco, Valentina; Villar, Paulina; Cataldo, Luis; Marcelain Cubillos, Katherine; Armisen Yáñez, Ricardo; Varas Godoy, Manuel; Fernández, Cristina; Tapia, Julio (Impact Journals LLC, 2015)
      Endothelin-converting enzyme-1c (ECE-1c) is a membrane metalloprotease involved in endothelin-1 synthesis, which has been shown in vitro to have a role in breast, ovary and prostate cancer cell invasion. N-terminal end of ...
    • Efecto de progesterona y estradiol sobre la expresión de marcadores de implantación y propiedades de células ... 
      Venegas Duarte, Sebastian Raul. (Universidad de Chile, 2017)
      Las células madre mesenquimales (MSC) son un grupo heterogéneo de células multipotentes que han adquirido gran importancia en el último tiempo debido a su potencial aplicación en el desarrollo de terapias celulares. La ...
    • Frizzled-1 receptor regulates adult hippocampal neurogenesis 
      Mardones, Muriel D.; Andaur, Gabriela A.; Varas Godoy, Manuel; Henriquez, Jenny F.; Salech Morales, Felipe; Behrens Pellegrino, María Isabel; Couve Correa, Andrés; Inestrosa, Nibaldo C.; Varela Nallar, Lorena (BioMed Central Ltd., 2016)
      © 2016 Mardones et al. Background: In the adult hippocampus new neurons are continuously generated from neural stem cells (NSCs) present at the subgranular zone of the dentate gyrus. This process is controlled by Wnt ...
    • Two Chronic Stress Models Based on Movement Restriction in Rats Respond Selectively to Antidepressant Drugs: ... 
      Ampuero, Estibaliz; Luarte, Alejandro; Santibáñez, Marcos; Varas Godoy, Manuel; Toledo, Jorge; Díaz Véliz, Emma; Cavada Chacón, Gabriel; Rubio, F. Javier; Wyneken, Úrsula (Oxford University Press, 2015)
      Background: Clinically depressed individuals respond to different types of antidepressants, suggesting that different neurobiological mechanisms may be responsible for their depression. However, animal models to characterize ...
    • Vaccination-induced skin-resident memory CD8(+) T cells mediate strong protection against cutaneous melanoma 
      Gálvez Cancino, Felipe; López, Ernesto; Menares, Evelyn; Díaz, Ximena; Zapata Flores, Camila; Cáceres, Pablo; Hidalgo, Sofía; Chovar, Ornella; Alcántara Hernández, Marcela; Borgna, Vicenzo; Varas Godoy, Manuel; Salazar Onfray, Flavio; Idoyaga, Juliana; Lladser, Álvaro (Taylor & Francis, 2018)
      Memory CD8(+) T cell responses have the potential to mediate long-lasting protection against cancers. Resident memory CD8(+) T (Trm) cells stably reside in non-lymphoid tissues and mediate superior innate and adaptive ...